I have my pictures stored on OneDrive, and have used the option to "free space" to remove the pictures from my local hard drive and have them only available on OneDrive. It appears that when I try to search the OneDrive Pictures folder, DupHunter wants to download all the pictures to my local drive.
If it is not possible to search for duplicates without having the files local, then I don't see that this program will be of use to me.